Summary Card
Overview of Laser Fundamentals
Laser resurfacing works by delivering controlled thermal injury to skin targets such as water, haemoglobin, or melanin. Device selection depends on target depth, thermal effect, healing profile, and pigmentation risk.
Indications and Suitability
Laser resurfacing is considered for photoageing, rhytides, acne scars, selected traumatic or surgical scars, and some disease-related skin problems; defer treatment for active herpetic lesions, recent sunburn or overexposure, and pregnancy or breastfeeding.
Applied Skin and Laser Anatomy
Resurfacing decisions depend on water-rich epidermal and dermal targets, thermal spread, adnexal re-epithelialisation, regional skin thickness, and danger areas such as eyelids, neck, and scarred skin.
Assessment and Planning
Before resurfacing, assess indications, scar or rhytid pattern, Fitzpatrick phototype, pigmentation risk, HSV and keloid history, medication risks, healing capacity, photographs, and whether laser alone is sufficient.
Device and Technique Selection
Choose the device by target depth, scar or wrinkle morphology, skin type, downtime tolerance, and risk: CO2 for stronger tightening and remodelling, Er:YAG for precise ablation, fractional approaches for staged healing, and adjuncts for mixed pathology.
Operative Principles
Safe resurfacing requires correct preparation, eye and airway protection, analgesia, conservative parameter selection, endpoint recognition, controlled overlap, plume management, and immediate barrier support.
Complications
Complications include early burns, pain, infection, and HSV reactivation, delayed acneiform eruption and erythema, pigment change, scarring, ectropion, and unsatisfactory or incomplete correction.
Postoperative Care and Surveillance
Postoperative care protects the barrier, prevents infection, controls inflammation, enforces sun avoidance, restarts skincare gradually, and reviews early enough to detect HSV, bacterial infection, pigment change, delayed healing, or scarring.
Outcomes and Counselling
Laser resurfacing improves texture, rhytides, dyspigmentation, and selected scars, but results vary by indication, skin type, device, and treatment intensity. Most patients improve rather than achieve complete correction.
Overview of Laser Fundamentals
Laser resurfacing works by delivering controlled thermal injury to skin targets such as water, haemoglobin, or melanin. Device selection depends on target depth, thermal effect, healing profile, and pigmentation risk.
Laser resurfacing devices differ by wavelength, chromophore target, depth of penetration, and degree of thermal injury. Understanding these differences helps trainees choose the correct device for texture, pigment, vascularity, or scar remodelling.
| Laser Type | Main Target | Main Effect | Common Uses | Main Trade-off |
|---|---|---|---|---|
| CO2 | Water | Ablation + coagulation | Deep rhytides, scars, tightening | More downtime and pigment risk |
| Er:YAG | Water | Precise ablation with less thermal spread | Superficial rhytides, texture, darker skin | Less contraction/remodelling |
| Fractional lasers | Water (fractionated columns) | Microscopic treatment zones with faster healing | Acne scars, rejuvenation | Often requires multiple sessions |
| Non-ablative lasers | Dermal water/chromophores | Dermal remodelling without epidermal removal | Mild texture/pigment change | More gradual improvement |
| Vascular lasers (e.g. PDL) | Oxyhaemoglobin | Vascular targeting | Erythema, telangiectasia | Does not resurface texture |
| Pigment lasers | Melanin | Pigment reduction | Lentigines, dyschromia | Higher PIH risk in darker skin |
Think in terms of chromophores and thermal injury
The clinical effect of a laser depends on:
- the chromophore absorbing energy,
- the depth of penetration,
- and the amount of collateral thermal spread.
In resurfacing:
- CO2 produces more coagulation and collagen contraction,
- Er:YAG produces cleaner ablation with less thermal damage,
- and fractional delivery leaves untreated skin between columns to accelerate healing.
Indications and Suitability
Laser resurfacing is considered for photoageing, rhytides, acne scars, selected traumatic or surgical scars, and some disease-related skin problems; defer treatment for active herpetic lesions, recent sunburn or overexposure, and pregnancy or breastfeeding.
Laser resurfacing improves surface texture, dyschromia, fine-to-moderate rhytides, and selected scars by controlled epidermal and dermal injury. It does not correct significant facial descent, deep volume loss, eyelid malposition, or unrealistic expectations.
Match the indication to what resurfacing can actually change
The best indication is a visible skin-quality problem where controlled injury and remodelling can improve contour, texture, or pigment.
- Photoageing: resurfacing may be used for skin-ageing changes such as rhytides and actinic texture change. 2
- Acne scarring: ablative fractional CO2 is a supported option for improving acne scars.
- Postoperative scars: patients with post-Mohs scars can be counselled for laser as a less invasive scar-revision option with reported safety and satisfaction. 4
- Damaged skin: ablative resurfacing may be considered for photodamage, acne scars, hidradenitis-related scarring, and selected posttraumatic or post-excision scars.
Choose suitability before choosing the machine
Suitability depends on skin type, healing capacity, pigmentation risk, downtime tolerance, and the depth of the problem.
- Fractional CO2 candidate: facial rejuvenation is best suited to Fitzpatrick I–III patients aged 40–60 with moderate-to-advanced wrinkles and mild-to-moderate dyspigmentation. 1
- Darker skin: Er:YAG is often preferred for darker-skinned patients undergoing cutaneous resurfacing. 6
- Milder change: short-pulsed Er:YAG suits mild rhytides, mildly atrophic scars, and textural changes from fibrosis or dermatochalasis. 6
- Broader Er:YAG use: Er:YAG may be considered across skin types and body sites for indications from lentigines to deeper rhytides.
Decline when resurfacing will create risk without benefit
Do not offer resurfacing to solve the wrong problem. Patients with brow ptosis, jowling, lower lid laxity, marked laxity, or deep tethered scars usually need another procedure or combination treatment.
- Active skin disease: postpone if infection, inflammatory flare, poor barrier function, or recent aggressive treatment is present.
- Healing risk: review keloid tendency, immunosuppression, smoking, radiation, and previous poor wound healing.
- Expectation mismatch: decline if the patient expects lifting, scar erasure, or permanent reversal of ageing.
- Timing conflict: avoid treatment immediately before unavoidable sun exposure or events requiring rapid social recovery.
Applied Skin and Laser Anatomy
Resurfacing decisions depend on water-rich epidermal and dermal targets, thermal spread, adnexal re-epithelialisation, regional skin thickness, and danger areas such as eyelids, neck, and scarred skin.
Laser resurfacing is a controlled injury. The trainee must understand where the energy goes, how heat spreads, and which skin units must survive for safe healing.
Treat water as the main ablative target
Ablative resurfacing works because water-containing tissue absorbs energy, vaporises, and leaves a predictable wound with surrounding thermal effect.
- CO2 concept: ablative fractional lasers are planned as water-targeting devices that create injury to drive re-epithelialisation and remodelling. 4
- Er:YAG concept: Er:YAG has a higher affinity for water-containing tissue, supporting finer ablation when precision is prioritised.
- Thermal relaxation: pulse duration and stacking determine whether heat remains localised or spreads into adjacent dermis.
- Coagulation zone: more coagulation may improve haemostasis and contraction, but increases erythema, dyspigmentation, and scarring risk.
Plan fractional injury around columns and reservoirs
Fractional treatment leaves untreated skin between treatment zones, which provides epithelial reservoirs for faster closure.
- Microcolumns: fractional CO2 creates microablative columns through the epidermis into the dermis, relevant for scar remodelling and topical adjuvant delivery. 8
- Healing reservoir: hair follicles, sebaceous units, and untreated intervening skin support re-epithelialisation.
- Expected closure: microablative columns typically re-epithelialise within 2–3 days after fractional CO2 treatment. 8
- Nonfacial caution: neck, chest, and extremity skin have fewer adnexal reservoirs and tolerate aggressive resurfacing poorly.
Respect thin skin and functional borders
The same energy is not equally safe across all regions. Thin skin and scarred skin magnify thermal injury.
- Eyelids: thin skin, globe proximity, and ectropion risk require conservative settings and eye protection.
- Neck: reduced adnexal density and mobile skin increase scarring and pigment risk.
- Mandibular edge: visible transition lines occur if resurfacing stops abruptly.
- Scarred fields: previous surgery, radiation, burns, or undermining reduce vascular reserve.
Use chromophores to avoid the wrong laser
Laser choice should follow the target, not the brand name.
- Water: CO2 and Er:YAG target water for ablation and resurfacing.
- Oxyhaemoglobin: pulsed dye laser is anatomically aligned with erythema and telangiectasia treatment. 4
- Melanin: pigment-targeting requires caution in darker phototypes because competing epidermal melanin increases dyspigmentation risk.
Assessment and Planning
Before resurfacing, assess indication, scar or rhytid pattern, Fitzpatrick phototype, pigmentation risk, HSV and keloid history, medication risks, healing capacity, photographs, and whether laser alone is sufficient.
Assessment prevents the common errors: treating the wrong diagnosis, overtreating high-risk skin, and promising a result that the laser cannot deliver.
Take a history that changes the plan
The history should identify infection risk, pigment risk, photosensitivity, impaired healing, and poor timing.
- HSV history: ask about cold sores, previous outbreaks after procedures, and current prodromal symptoms.
- Medication risk: document isotretinoin exposure, photosensitising drugs, anticoagulants, immunosuppression, retinoids, and recent peels.
- Pigment behaviour: ask about tanning, post-inflammatory hyperpigmentation, melasma, and prior laser response.
- Healing history: record keloids, hypertrophic scars, radiation, smoking, diabetes, connective tissue disease, and poor wound healing.
Skin type is a planning variable, not a label
Phototype informs risk, settings, staging, and counselling.
- Fitzpatrick classification: the Fitzpatrick system is the most widely accepted phototyping method, based on sunburn tendency and tanning ability. 9
- Prediction value: skin phototyping helps predict outcomes of aesthetic procedures. 9
- Pigment risk: higher phototypes, melasma tendency, and recent UV exposure push planning toward staged, conservative treatment.
- Documentation: record baseline pigment, scars, rhytids, laxity, and asymmetry before treatment.
Examine the deformity before choosing the laser
Not all wrinkles or scars respond to resurfacing alone. Classify the dominant problem before discussing devices.
- Rhytids: separate fine etched lines from dynamic wrinkles, folds, and laxity.
- Acne scars: classify ice-pick, boxcar, rolling, hypertrophic, and mixed patterns.
- Ice-pick scars: assess for adjunctive or combination treatment rather than laser monotherapy alone.
- Atrophic scars: choose adjuncts according to scar type, severity, and number. 10
Build the plan around severity, skin type, and downtime
Planning should end with a clear decision: treat now, modify, stage, combine, or defer.
- Acne scar planning: session number, interval, parameters, phototype, scar severity, and scar type affect fractional CO2 effectiveness. 11
- Facial ageing: treatment area, wrinkle depth, phototype, and dyspigmentation tendency should guide fractional ablative CO2 settings.
- Skin preparation: no universal consensus protocol exists for preprocedural skin preparation before ablative resurfacing, so document the local protocol you are using. A typical regimen is sun avoidance, cessation of retinoids or irritants several days before treatment, antiviral prophylaxis for HSV-risk patients, and pigment suppression such as hydroquinone in selected higher-risk phototypes. 12
- Consent record: document target, expected improvement range, downtime, pigment risk, infection risk, scarring risk, and need for staged treatment.
Decide whether to proceed, modify, or defer
Use a simple pre-treatment decision frame.
- Proceed: stable skin, suitable indication, realistic goals, acceptable pigment risk, and planned prophylaxis.
- Modify: darker phototype, melasma risk, mixed scars, eyelid or neck treatment, or limited downtime.
- Combine: tethered scars, ice-pick scars, volume deficit, dynamic wrinkles, or residual vascular redness.
- Defer: active infection, recent UV injury, pregnancy or breastfeeding, active dermatitis, poor adherence, or unstable expectations.
Device and Technique Selection
Choose the device by target depth, scar or wrinkle morphology, skin type, downtime tolerance, and risk: CO2 for stronger tightening and remodelling, Er:YAG for precise ablation, fractional approaches for staged healing, and adjuncts for mixed pathology.
The device is only part of the decision. The trainee must also choose density, energy, number of sessions, intervals, and whether another modality is needed.
Select the device by the dominant clinical problem
The safest selection framework starts with the clinical target, then accepts the trade-off.
| Dominant problem | Best-fit option | Main trade-off |
|---|---|---|
| Deep rhytides, photodamage, contraction needed | CO2 resurfacing | More thermal effect and downtime |
| Fine rhytides, superficial texture, higher risk skin | Er:YAG | Less dramatic remodelling expected |
| Acne scarring with mixed depth | Fractional ablative laser | Multiple sessions often needed |
| Mild texture with low downtime priority | Non-ablative fractional laser | More gradual improvement |
| Red scar or telangiectasia | Vascular laser adjunct | Does not resurface texture |
| Pigment plus texture | Staged combination treatment | More visits and counselling |
Choose CO2 when efficacy matters more than morbidity
CO2 is favoured when collagen contraction, deeper remodelling, and visible rejuvenation are the main goals.
- Wrinkle efficacy: CO2 may offer greater efficacy for facial wrinkles, while Er:YAG may be favoured when complication profile is prioritised. 13
- Er:YAG limitation: Er:YAG should not be expected to produce the same dramatic clinical and histologic improvement as CO2.
- Combined ablation: combined CO2 and Er:YAG may be selected to maximise targeted collagen contraction while limiting postoperative morbidity.
- High-risk areas: reduce energy, density, or passes around eyelids, neck, bony prominences, and prior scars.
Stage treatment when pigment risk is higher
Higher pigment risk should push the plan toward lower intensity, staged sessions, and strict sun control.
- Fitzpatrick III–IV: technique intensity should generally be reduced and staged across sessions compared with single higher-setting treatment in Fitzpatrick I–II skin. 1
- Dark or sensitive skin: fractional radiofrequency or needling may be lower-risk alternatives or adjuncts. 10
- Dark acne scarring: PRP or fractional radiofrequency microneedling added to fractional laser may improve efficacy and reduce PIH.
- Melasma tendency: avoid aggressive heat-based treatment unless the indication and counselling are strong.
Combine only when the second treatment solves a defined problem
Combination therapy should not become automatic. Add treatments only for tethering, deep scars, vascularity, pigment, or downtime control.
- Deep acne scars: fractional laser may need subcision or punch techniques rather than laser alone.
- Vascular redness: use vascular laser adjuncts such as pulsed dye laser (PDL) when erythema or telangiectasia is the residual target.
- Radiofrequency caution: adding radiofrequency to CO2 should not be assumed to improve results and may prolong erythema. 2
- Treatment sequencing: avoid stacking multiple inflammatory procedures in high-risk skin without a staged plan.
Operative Principles
Safe resurfacing requires correct preparation, eye and airway protection, analgesia, conservative parameter selection, endpoint recognition, controlled overlap, plume management, and immediate barrier support.
Operative failure usually comes from excessive energy, unsafe overlap, poor regional adjustment, inadequate protection, or missed infection risk.
Prepare the patient, room, and team before firing
Laser resurfacing is a controlled burn performed in a shared safety environment.
- Consent pause: confirm indication, target zones, settings, prophylaxis, and expected endpoint.
- Skin preparation: choose cleansing agents cautiously because efficacy and safety evidence for pre-laser preparation is sparse. 12
- Eye safety: use wavelength-specific eyewear and corneal shields for eyelid or periocular treatment.
- Airway safety: avoid oxygen pooling, use wet towels where appropriate, and coordinate with anaesthesia.
Build analgesia into the workflow
Pain control is a procedural requirement, not an afterthought.
- Pain expectation: pain is common during dermatological laser procedures, so analgesia should be planned.
- Anaesthesia choice: active non-invasive anaesthesia is preferable to none; topical anaesthetics and pneumatic flattening appear more effective than cooling.
- Topical protocol: lidocaine/tetracaine 7%/7% peel cream was applied 45 minutes before fractional resurfacing and removed immediately before treatment in a trial. 15
- Effect size: that cream reduced mean pain from 8.6 to 3.0 on a 10-cm VAS in a 30-patient trial. 15
Choose settings to hit the target, not the maximum
Parameters should be set to the indication, skin thickness, region, and risk profile.
- Target logic: wavelength and fluence should affect the intended target while limiting collateral injury during scar resurfacing. 4
- Fractional variables: energy, density, pulse duration, coverage, and passes determine depth and thermal burden.
- Non-ablative Er:YAG: settings should account for superficial temperature rise, partial epithelial preservation, and subepithelial matrix coagulation. 16
- Er:YAG margin: precise ablation with less thermal injury supports shorter healing times and a greater safety margin. 7
Execute in a controlled sequence
Order matters because erythema, oedema, smoke, and bleeding obscure endpoints.
- Confirm the map: mark treatment boundaries, transition zones, scars, and regions needing reduced settings.
- Boundary control: feather edges to avoid visible stop lines.
- Regional adjustment: reduce intensity over eyelids, neck, thin skin, and scars.
- Treat by aesthetic unit: work systematically so overlapped and skipped zones are visible.
- Overlap control: avoid pulse stacking unless deliberately planned.
- Endpoint check: stop when the planned clinical endpoint appears, not after a fixed number of passes.
- Control plume and debris: visibility and staff safety deteriorate quickly without active evacuation.
- Plume control: use smoke evacuation close to the treatment field.
- Debris removal: wipe gently according to device protocol without traumatising the wound.
- Dress immediately: the wound should leave theatre protected, cooled, and documented.
- Immediate care: apply the agreed occlusive or open-care regimen.
- Record: document device, settings, passes, endpoints, adjuncts, and complications.
Complications
Complications include early burns, pain, infection and HSV reactivation, delayed acneiform eruption and erythema, pigment change, scarring, ectropion, and unsatisfactory or incomplete correction.
Complications should be organised by timing and consequence. Escalate severe pain, spreading erythema, purulence, vesicles, visual symptoms, delayed healing, or early contracture.
Recognise early problems before they scar
Early complications are often treatable if identified before deeper injury or infection develops.
- Thermal injury: excessive pain, blistering, grey tissue, or sharply demarcated burns require senior review.
- Infection: pustules, honey crusting, malodour, spreading erythema, or systemic symptoms need swab and treatment.
- HSV: grouped vesicles, disproportionate pain, or known HSV history warrants prompt antiviral treatment.
- Acneiform eruption: occlusion, ointments, and inflammation may trigger papules or pustules.
Counsel pigment change as common in the right context
Dyspigmentation is central to consent, especially for acne scarring, darker skin, melasma tendency, and UV exposure.
- Acne scars: pigment changes after facial acne scar resurfacing were reported in up to 44% and usually lasted a few weeks.
- CO2 and Er:YAG: reported complications include erythema, hyperpigmentation, crusting, and rarely hypopigmentation. 13
- Expert experience: hyperpigmentation, contact dermatitis, and local infection were commonly discussed after fractional ablative CO2 resurfacing.
- Late pigment loss: hypopigmentation can be delayed and difficult to reverse.
Treat scarring and ectropion as high-consequence events
Scarring is uncommon but unacceptable when preventable. Watch functional borders closely.
- Overall adverse events: a systematic review of 1093 resurfacing patients reported adverse events in 106 patients, or 9.7%. 5
- Hypertrophic scarring: hypertrophic scarring was rare in that review, reported in five patients. 5
- Facelift combination: in simultaneous facelift and laser resurfacing, ectropion was reported in 0.12% and hypertrophic scarring in 0.51%. 18
- Escalation triggers: delayed epithelialisation, lid retraction, contracture, or expanding hypertrophic scar needs early specialist intervention.
Postoperative Care and Surveillance
Postoperative care protects the barrier, prevents infection, controls inflammation, enforces sun avoidance, restarts skincare gradually, and reviews early enough to detect HSV, bacterial infection, pigment change, delayed healing, or scarring.
Postoperative instructions must be specific to the device, depth, region, and patient risk. Generic “keep it clean” advice is not enough.
Protect the wound until the barrier recovers
The first priority is cooling, comfort, moisture balance, and avoidance of trauma.
- Immediate care: cold compresses and topical petrolatum are commonly used after fractional ablative CO2 resurfacing. 1
- Occlusive care: petrolatum-based regimens reduce desiccation and friction over ablative wounds.
- Open care: lighter regimens may be used for less aggressive fractional or non-ablative treatment.
- Analgesia: prescribe simple analgesia and escalate if pain is worsening rather than settling.
Prevent infection while recognising protocol variation
Prophylaxis should follow local policy and patient risk, with a low threshold to treat suspected infection.
- HSV prophylaxis: expert consensus supports valacyclovir 500 mg for 5–7 days starting the day before or day of fractional ablative CO2 resurfacing.
- Bacterial prophylaxis: most expert panelists recommend it for fractional ablative CO2 resurfacing, but antibiotic choice is not standardised. 1
- Red flags: vesicles, purulence, spreading erythema, fever, severe pain, or delayed healing require review.
- Swabs: culture suspicious crusting, pustules, or non-healing areas before changing treatment blindly.
Control inflammation and pigment risk
Sun exposure and premature active skincare can convert an uncomplicated procedure into dyspigmentation.
- Sun avoidance: strict photoprotection is mandatory while erythema and barrier disruption persist.
- Active skincare: active ingredients are generally restarted gradually between days 8 and 42 once healing permits. 1
- Erythema expectation: reviewed rejuvenation studies reported erythema around 12.8 days with combination treatment versus 15.24 days with monotherapy. 2
- Pigment surveillance: review earlier in darker skin, melasma tendency, or any new brown-grey change.
Use follow-up to detect both complications and opportunities
Surveillance is not only complication screening. It also identifies whether further scar or texture treatment is appropriate.
- Early review: check epithelialisation, pain trajectory, infection signs, and adherence.
- Later review: assess erythema, pigment, contour, scar softening, and need for staged treatment.
- Mohs scars: laser scar revision after Mohs has been reported from immediately post-procedure through 4 years later. 4
- Perioral treatment: adverse events after perioral rejuvenation should be recognised early so treatment can start without delay. 19
Outcomes and Counselling
Laser resurfacing improves texture, rhytides, dyspigmentation, and selected scars, but results vary by indication, skin type, device, and treatment intensity. Most patients improve rather than achieve complete correction.
Counselling should focus on expected improvement, downtime, pigment risk, need for staged treatment, and the limitations of resurfacing compared with lifting or volume-restoration procedures.
Counsel improvement, not perfection
Patients should understand that:
- Laser resurfacing improves rather than completely removes wrinkles, scars, or pigment abnormalities.
- Several months may be required for maximal collagen remodelling and final results.
- Multiple treatment sessions are often required, particularly for acne scars, non-ablative resurfacing, and darker skin types.
- Laser resurfacing improves skin quality but does not replace procedures that address skin laxity, facial descent, or volume loss.
- Maintenance treatments and ongoing sun protection help preserve long-term results.
Match expectations to downtime and risk
More aggressive treatment generally increases:
- Wrinkle reduction and skin tightening.
- Collagen remodelling.
- Improvement in deeper scars and photodamage.
but also increases:
- Recovery time and postoperative erythema.
- Risk of post-inflammatory hyperpigmentation, particularly in darker phototypes.
- Risk of infection, prolonged healing, and scarring.
- Need for meticulous wound care and strict photoprotection.
References
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[2] Pour et al.. A systematic review and meta-analysis of efficacy, safety, and satisfaction rates of laser combination treatments vs laser monotherapy in skin rejuvenation resurfacing.. Lasers in medical science. 2023. doi:10.1007/s10103-023-03856-5
[3] Xu et al.. Ablative Fractional CO2 Laser for Facial Atrophic Acne Scars.. Facial plastic surgery : FPS. 2018. doi:10.1055/s-0037-1606096
[4] Le et al.. Laser Applications in Wound and Scar Management Post-Mohs Micrographic Surgery: A Systematic Review\.. Journal of cutaneous medicine and surgery. 2024. doi:10.1177/12034754241227629
[5] Mirza et al.. Outcomes and adverse effects of ablative vs nonablative lasers for skin resurfacing: A systematic review of 1093 patients.. Dermatologic therapy. 2021. doi:10.1111/dth.14432
[6] Alster et al.. Erbium:YAG cutaneous laser resurfacing.. Dermatologic clinics. 2001. doi:10.1016/s0733-8635(05)70286-2
[7] Caniglia. Erbium:YAG laser skin resurfacing.. Facial plastic surgery clinics of North America. 2004. doi:10.1016/j.fsc.2004.03.005
[8] Kwon et al.. Combination Treatment with Human Adipose Tissue Stem Cell-derived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study.. Acta dermato-venereologica. 2020. doi:10.2340/00015555-3666
[9] Gupta et al.. Skin typing: Fitzpatrick grading and others.. Clinics in dermatology. 2019. doi:10.1016/j.clindermatol.2019.07.010
[10] Bhargava et al.. Acne Scarring Management: Systematic Review and Evaluation of the Evidence.. American journal of clinical dermatology. 2018. doi:10.1007/s40257-018-0358-5
[11] Ghazzawi et al.. A systematic review of evaluating the efficacy of acne scar treatment by Fractional Laser with or without using adjunctive treatments.. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology. 2021. doi:10.1080/14764172.2022.2033785
[12] Cox et al.. Skin Preparation for Photodynamic Therapy, Chemexfoliation, and Ablative Laser Resurfacing: a Systematic Literature Review\.. Dermatologic surgery : official publication for American Society for Dermatologic Surgery \[et al.]. 2021. doi:10.1097/DSS.0000000000003026
[13] Chen et al.. A systematic review of comparative studies of CO 2 and erbium:YAG lasers in resurfacing facial rhytides (wrinkles).. Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology. 2017. doi:10.1080/14764172.2017.1288261
[14] Greveling et al.. Non-invasive anaesthetic methods for dermatological laser procedures: a systematic review\.. Journal of the European Academy of Dermatology and Venereology : JEADV. 2017. doi:10.1111/jdv.14130
[15] Caprari et al.. Assessment of clinical efficacy of lidocaine/tetracaine 7%/7% peel cream in fractional microablative laser procedure-associated pain for facial skin aging treatment. A randomized, controlled, single-blind trial.. Journal of cosmetic dermatology. 2022. doi:10.1111/jocd.14296
[16] Hympanova et al.. Effects of non-ablative Er:YAG laser on the skin and the vaginal wall: systematic review of the clinical and experimental literature.. International urogynecology journal. 2020. doi:10.1007/s00192-020-04452-9
[17] Jordan et al.. Laser resurfacing of the skin for the improvement of facial acne scarring: a systematic review of the evidence.. The British journal of dermatology. 2000. doi:10.1046/j.1365-2133.2000.03350.x
[18] Wen et al.. Laser Resurfacing at the Time of Facelift Surgery: A Systematic Review and Meta-Analysis.. Aesthetic surgery journal. 2026. doi:10.1093/asj/sjaf203
[19] Sayan et al.. Adverse reactions associated with perioral rejuvenation using laser, fat and hyaluronic acid: systematic review\.. The British journal of oral & maxillofacial surgery. 2021. doi:10.1016/j.bjoms.2021.02.027