MSLT II Trial - Summary and Journal Club

This was a landmark paper in the management of melanoma. The authors answered a very important question - what is the actual efficacy of lymph node clearance in melanoma patients with positive sentinel lymph nodes?
MSLT II Trial - Summary and Journal Club

Summary Card

Level of Evidence: 1

Background
What is the actual effect of lymph node clearance in melanoma patients with a positive sentinel node?

Methods
Randomised control trial over a 10-year period in which patients were observed (clinical examination and USS) or lymph node clearance.

Results
Lymph node clearance did not increase melanoma-specific survival and increased surgical complications.

Conclusion
Clinical observation with frequent physical exams and ultrasonography is reasonable for certain patients with a positive SLNB


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