Breast Implant associated Anaplastic Large Cell Lymphoma (Bi-ALCL) is linked to textured implants. It should be suspected in patients with late-onset seroma. It can be confirmed cytologically and histologically.
5 Key Points
- Uncommon lymphoma linked to textured, high surface grade, implants.
- Incidence is increasing as awareness increases.
- Late-onset seromas should be urgently investigated with cytology and histology.
- Tumour Markers are CD30+ and ALK-
- Early stage disease is curable with surgery alone.
Breast implant-associated Anaplastic Large Cell Lymphoma (Bi-ALCL) is a CD30+, ALK-, T-cell derived lymphoma. It fits within the non-Hodgkin lymphoma group and is linked to textured breast implants.
A unifying hypothesis of published literature suggests textured implants with a high surface grade, bacterial contamination, inflammation and patient susceptibility interact over time to produce T-cell transformation. It is multifactorial, like most carcinogenesis
- Textured implants creates inflammation from friction
- High surface grade acts as passive conduit for bacterial proliferation
- Bacterial contamination is a form of microbiome induction that potentiates carcinogenesis. This is suggested by cluster patterns of incidence, biofilm formation and growth of both gram-positive and negative organisms.
Wide variations in published data from 1 in 3,000 to 1 in 3,000,000. This variation is due to geographic discrepancies in databases and the different type of textured implants available. Importantly, the incidence is increasing each year.
History and Examination
- Insidious onset
- Late onset seroma (>1 year post implant), most commonly 8 years after implants inserted.
- Firm mass and lymphadenopathy (advanced disease)
- Capsular contracture (non-specific)
- Textured Implants (no reports of link to smooth implants), particularly those with high surface grade classification (large surface area and rough)
- Immunocompromised patient
A multi-disciplinary approach is needed between surgeon, histology, radiology and, if diagnosed, oncology teams.
A pre-operative Ultrasound-guided seroma aspirate should be investigated for
- Cytology: large anaplastic cells
- Flow cytometry: aberrant T-Calls
- Immunohistochemistry: CD30+ and ALK- makers.
Intra-operative specimens of any residual seroma and the implant capsule should be sent at the time of capsulectomy.
The absence of tumour cells following a positive seroma aspiration does not suggestion regression or resolution, but rather a lowering of the tumour cell burden following the drainage of the malignant seroma.
This does not assist in diagnosing or staging but it is interesting to note the growth of both gram-positive and negative bacteria. This is different to capsular contracture pathophysiology, which mainly grows solely gram-positive bacteria.
The aim of the investigations to diagnose and appropriately stage the patient.
|IA (negative)||Seroma Positive, Capsule Negative||63%|
|IA (positive)||Seroma Positive, Luminal Capsule Positive||16%|
|IIA||Mass extending beyond Capsule||11%|
|III||Metastatic disease with 1 axillary node||1%|
|III||Metastatic disease with multiple nodes||1%|
There are no standardised guidelines referencing the role of further radiology investigations. This should be considered as a case-by-case basis in addition to the ultrasound for guided seroma aspiration.
Management of this condition begins in the pre-operative setting by ensuring the patient has received informed consent and they understand the risk of Bi-ALCL
Intra-operatively, efforts should be focused on disease prevention through implant choice and reducing implant contamination.
Early recognition is key. Following the diagnosis, staging and multi-disciplinary team input, surgery is next.
Options to consider:
- Open Capsulectomy of anterior and/or posterior wall
- Implant replacement with a smooth implant
Surgical treatment of Bi-ALCL. Courtesy of Dr Tim Papadopoulos
Stage 1A is indolent and curable through surgery alone.
Recent publications have suggested a screening programme, but this has not been formally introduced.